diff --git a/Source/Core/VideoBackends/D3D/D3DMain.cpp b/Source/Core/VideoBackends/D3D/D3DMain.cpp
index 9f75712ccd..b217218986 100644
--- a/Source/Core/VideoBackends/D3D/D3DMain.cpp
+++ b/Source/Core/VideoBackends/D3D/D3DMain.cpp
@@ -106,6 +106,7 @@ void VideoBackend::FillBackendInfo()
   g_Config.backend_info.bSupportsSSAA = true;
   g_Config.backend_info.bSupportsShaderBinaries = true;
   g_Config.backend_info.bSupportsPipelineCacheData = false;
+  g_Config.backend_info.bSupportsCoarseDerivatives = true;
   g_Config.backend_info.bSupportsLogicOp = D3D::SupportsLogicOp(g_Config.iAdapter);
 
   g_Config.backend_info.Adapters = D3DCommon::GetAdapterNames();
diff --git a/Source/Core/VideoBackends/D3D12/VideoBackend.cpp b/Source/Core/VideoBackends/D3D12/VideoBackend.cpp
index 68496c9ed6..3a33832dc1 100644
--- a/Source/Core/VideoBackends/D3D12/VideoBackend.cpp
+++ b/Source/Core/VideoBackends/D3D12/VideoBackend.cpp
@@ -82,6 +82,7 @@ void VideoBackend::FillBackendInfo()
   g_Config.backend_info.AAModes = DXContext::GetAAModes(g_Config.iAdapter);
   g_Config.backend_info.bSupportsShaderBinaries = true;
   g_Config.backend_info.bSupportsPipelineCacheData = true;
+  g_Config.backend_info.bSupportsCoarseDerivatives = true;
 
   // We can only check texture support once we have a device.
   if (g_dx_context)
diff --git a/Source/Core/VideoBackends/Null/NullBackend.cpp b/Source/Core/VideoBackends/Null/NullBackend.cpp
index 5887d37391..17e31c4418 100644
--- a/Source/Core/VideoBackends/Null/NullBackend.cpp
+++ b/Source/Core/VideoBackends/Null/NullBackend.cpp
@@ -55,6 +55,7 @@ void VideoBackend::InitBackendInfo()
   g_Config.backend_info.bSupportsPartialDepthCopies = false;
   g_Config.backend_info.bSupportsShaderBinaries = false;
   g_Config.backend_info.bSupportsPipelineCacheData = false;
+  g_Config.backend_info.bSupportsCoarseDerivatives = false;
 
   // aamodes: We only support 1 sample, so no MSAA
   g_Config.backend_info.Adapters.clear();
diff --git a/Source/Core/VideoBackends/OGL/OGLMain.cpp b/Source/Core/VideoBackends/OGL/OGLMain.cpp
index 3ca79d5c85..375b1d12c7 100644
--- a/Source/Core/VideoBackends/OGL/OGLMain.cpp
+++ b/Source/Core/VideoBackends/OGL/OGLMain.cpp
@@ -99,7 +99,7 @@ void VideoBackend::InitBackendInfo()
   g_Config.backend_info.bSupportsGPUTextureDecoding = true;
   g_Config.backend_info.bSupportsBBox = true;
 
-  // Overwritten in Render.cpp later
+  // Overwritten in OGLRender.cpp later
   g_Config.backend_info.bSupportsDualSourceBlend = true;
   g_Config.backend_info.bSupportsPrimitiveRestart = true;
   g_Config.backend_info.bSupportsPaletteConversion = true;
@@ -107,6 +107,7 @@ void VideoBackend::InitBackendInfo()
   g_Config.backend_info.bSupportsDepthClamp = true;
   g_Config.backend_info.bSupportsST3CTextures = false;
   g_Config.backend_info.bSupportsBPTCTextures = false;
+  g_Config.backend_info.bSupportsCoarseDerivatives = false;
 
   g_Config.backend_info.Adapters.clear();
 
diff --git a/Source/Core/VideoBackends/OGL/OGLRender.cpp b/Source/Core/VideoBackends/OGL/OGLRender.cpp
index 782d5e1747..76064920f2 100644
--- a/Source/Core/VideoBackends/OGL/OGLRender.cpp
+++ b/Source/Core/VideoBackends/OGL/OGLRender.cpp
@@ -483,6 +483,8 @@ Renderer::Renderer(std::unique_ptr<GLContext> main_gl_context, float backbuffer_
       GLExtensions::Supports("GL_EXT_texture_compression_s3tc");
   g_Config.backend_info.bSupportsBPTCTextures =
       GLExtensions::Supports("GL_ARB_texture_compression_bptc");
+  g_Config.backend_info.bSupportsCoarseDerivatives =
+      GLExtensions::Supports("GL_ARB_derivative_control") || GLExtensions::Version() >= 450;
 
   if (m_main_gl_context->IsGLES())
   {
diff --git a/Source/Core/VideoBackends/OGL/ProgramShaderCache.cpp b/Source/Core/VideoBackends/OGL/ProgramShaderCache.cpp
index 021391e47c..8aba81b7ed 100644
--- a/Source/Core/VideoBackends/OGL/ProgramShaderCache.cpp
+++ b/Source/Core/VideoBackends/OGL/ProgramShaderCache.cpp
@@ -747,6 +747,7 @@ void ProgramShaderCache::CreateHeader()
       "%s\n"  // shader image load store
       "%s\n"  // shader framebuffer fetch
       "%s\n"  // shader thread shuffle
+      "%s\n"  // derivative control
 
       // Precision defines for GLSL ES
       "%s\n"
@@ -826,6 +827,9 @@ void ProgramShaderCache::CreateHeader()
           "#extension GL_ARB_shader_image_load_store : enable" :
           "",
       framebuffer_fetch_string.c_str(), shader_shuffle_string.c_str(),
+      g_ActiveConfig.backend_info.bSupportsCoarseDerivatives ?
+          "#extension GL_ARB_derivative_control : enable" :
+          "",
       is_glsles ? "precision highp float;" : "", is_glsles ? "precision highp int;" : "",
       is_glsles ? "precision highp sampler2DArray;" : "",
       (is_glsles && g_ActiveConfig.backend_info.bSupportsPaletteConversion) ?
diff --git a/Source/Core/VideoBackends/Software/SWmain.cpp b/Source/Core/VideoBackends/Software/SWmain.cpp
index a0aa8e03c1..ca1f4304dd 100644
--- a/Source/Core/VideoBackends/Software/SWmain.cpp
+++ b/Source/Core/VideoBackends/Software/SWmain.cpp
@@ -84,6 +84,7 @@ void VideoSoftware::InitBackendInfo()
   g_Config.backend_info.bSupportsShaderBinaries = false;
   g_Config.backend_info.bSupportsPipelineCacheData = false;
   g_Config.backend_info.bSupportsBBox = true;
+  g_Config.backend_info.bSupportsCoarseDerivatives = false;
 
   // aamodes
   g_Config.backend_info.AAModes = {1};
diff --git a/Source/Core/VideoBackends/Vulkan/VulkanContext.cpp b/Source/Core/VideoBackends/Vulkan/VulkanContext.cpp
index 6c58369204..16aa7872e7 100644
--- a/Source/Core/VideoBackends/Vulkan/VulkanContext.cpp
+++ b/Source/Core/VideoBackends/Vulkan/VulkanContext.cpp
@@ -286,6 +286,7 @@ void VulkanContext::PopulateBackendInfo(VideoConfig* config)
   config->backend_info.bSupportsLogicOp = false;                   // Dependent on features.
   config->backend_info.bSupportsLargePoints = false;               // Dependent on features.
   config->backend_info.bSupportsFramebufferFetch = false;          // No support.
+  config->backend_info.bSupportsCoarseDerivatives = true;          // Assumed support.
 }
 
 void VulkanContext::PopulateBackendInfoAdapters(VideoConfig* config, const GPUList& gpu_list)
diff --git a/Source/Core/VideoCommon/PixelShaderGen.cpp b/Source/Core/VideoCommon/PixelShaderGen.cpp
index b2a1166fd6..dd2d9f41ad 100644
--- a/Source/Core/VideoCommon/PixelShaderGen.cpp
+++ b/Source/Core/VideoCommon/PixelShaderGen.cpp
@@ -628,15 +628,35 @@ uint WrapCoord(int coord, uint wrap, int size) {{
               BitfieldExtract<&SamplerState::TM1::max_lod>("texmode1"));
 
     if (api_type == APIType::OpenGL || api_type == APIType::Vulkan)
-      out.Write(R"(
+    {
+      if (g_ActiveConfig.backend_info.bSupportsCoarseDerivatives)
+      {
+        // The software renderer uses the equivalent of coarse derivatives, so use them here for
+        // consistency.  This hasn't been hardware tested.
+        // Note that bSupportsCoarseDerivatives being false only means dFdxCoarse and dFdxFine don't
+        // exist.  The GPU may still implement dFdx using coarse derivatives; we just don't have the
+        // ability to specifically require it.
+        out.Write(R"(
+  float2 uv_delta_x = abs(dFdxCoarse(float2(uv)));
+  float2 uv_delta_y = abs(dFdyCoarse(float2(uv)));
+)");
+      }
+      else
+      {
+        out.Write(R"(
   float2 uv_delta_x = abs(dFdx(float2(uv)));
   float2 uv_delta_y = abs(dFdy(float2(uv)));
 )");
+      }
+    }
     else if (api_type == APIType::D3D)
+    {
+      ASSERT(g_ActiveConfig.backend_info.bSupportsCoarseDerivatives);
       out.Write(R"(
-  float2 uv_delta_x = abs(ddx(float2(uv)));
-  float2 uv_delta_y = abs(ddy(float2(uv)));
+  float2 uv_delta_x = abs(ddx_coarse(float2(uv)));
+  float2 uv_delta_y = abs(ddy_coarse(float2(uv)));
 )");
+    }
 
     // TODO: LOD bias is normally S2.5 (Dolphin uses S7.8 for arbitrary mipmap detection and higher
     // IRs), but (at least per the software renderer) actual LOD is S28.4.  How does this work?
diff --git a/Source/Core/VideoCommon/VideoConfig.h b/Source/Core/VideoCommon/VideoConfig.h
index 495eef6c28..d4307c479a 100644
--- a/Source/Core/VideoCommon/VideoConfig.h
+++ b/Source/Core/VideoCommon/VideoConfig.h
@@ -230,6 +230,7 @@ struct VideoConfig final
     bool bSupportsDepthReadback = false;
     bool bSupportsShaderBinaries = false;
     bool bSupportsPipelineCacheData = false;
+    bool bSupportsCoarseDerivatives = false;
   } backend_info;
 
   // Utility